This article is in three parts. Part 1 discusses the meaning, target and sources of stigma with emphasis on physique, social group membership, cognitive and neurological factors and life style preferences. Part 2 looked at the manifestations and effects of stigmatization such as labelling, discrimination, anxiety, with special attention to Ghana specific cases. The final part (3) deliberates on the way forward to stigma reduction through awareness creation and sensitization. Others are community involvement and the role of faith-based institutions as well as work place policies and the critical role of the media.