Debutants Edubiase United halted leaders Kessben FC 2-1 at the Len Clay Sports Stadium in Glo Premier League and Asante Kotoko suffered their second defeat of the campaign at the hands of bogey-side Heart of Lions.
Nuhu Fuseini opened the scoring the send the newly-installed side to go into the break and Seidu Bamson added a second a minute after the break.
James Boadu gave Kessben some hope by pulling one back two minutes later.
Tanko Mohammed's 11th minute header gave Heart of Lions the much-needed win to move to fourth-place.
Samad Oppong was red-carded in the second half for a ruthless challenge on his marker.
Hearts of Oak bounced back after their mid-week loss to Aduana Stars in a 2-1 win over Chelsea of Bechem at the Cape-Coast Park.
Obed Ansah nicked a goal on the stroke of half-time before Tua Khemis added the second in the 49th minute.
Chelsea reduced the deficit in the 81st minute through Kankani Salifu who profited from a rebound.
Berekum Arsenals needed a penalty which was converted by Francis Aggrey in beat a 9-man AshantiGold 2-1 at the Golden City Park.
Aggrey gave the homesters the lead before Euguene Owusu drew level.
King Faisal who began the weekend without head coach Isaac Opeele Boateng lost 1-2 to All Stars at the Baba Yara Stadium.
Ofosu Mickey gave the Faisal the lead in the 8th minute and Nathaniel Asamoah grabbed a brace to seal it for the visitors.
Real Tamale Stadium fought hard to seal a 3-2 victory Great Olympics with Abdul Aziz Yusif getting a brace for the home team.
Liberty Professionals compounded the woes of Eleven Wise with a 2-0 win at the Karl Reindorf Park in Dansoman.