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At least 25 people have been killed and dozens injured in a suicide bombing on a Shia Muslim march in the Pakistani city of Karachi, officials say. The attacker had been walking amidst a procession with tens of thousands of people, said the interior minister. After the explosion, marchers turned their anger on ambulance workers, security forces and journalists. Pakistan's security forces have been on high alert as Shia Muslims marked the holy month of Muharram, or Ashura. Monday was the climax of the holy period, which commemorates the death of the Prophet Muhammad's grandson. There was no immediate claim of responsibility, which comes amid an upsurge of attacks by Taliban militants in Pakistan. Smashed ambulances Karachi has a long history of sectarian violence between Shias and Sunnis. There have been numerous attacks on such processions across the country over the last few days, says the BBC's Aleem Maqbool. On Sunday, eight people were killed when a suicide bomber targeted a Shia march in Pakistan-administered Kashmir. Interior Minister Rehman Malik blamed Monday's blast on extremists who wanted to destabilise Pakistan. "Whoever has done this, he cannot be a Muslim. He is worse than an infidel," he told reporters. Karachi police chief Waseem Ahmed said the severed head of the bomber had been found, reports Reuters news agency. One survivor, Naseem Raza, told AP news agency: "I saw walls stained with blood and splashed with human flesh. I saw bloodstained people lying here and there." Fleeing the scene of the blast, another mourner told told AFP news agency: "My sister, her husband and children are dead." The bombing unleashed further pandemonium as angry Shia mourners fired shots in the air. Rioters torched dozens of shops and vehicles, while members of the security forces who had been guarding the procession were pelted with stones. TV footage showed smashed police vehicles and ambulances. Karachi Mayor Mustafa Kamal appealed for calm. Sectarian violence"I want to appeal to the people, to my brothers, my elders to stay calm. I am hearing people are clashing with police and doctors.